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La GCL es considerada la enzima limitante de la velocidad de sntesis ya que la sobreexpresin de GS no aumenta los niveles de GSH en tanto que la sobreexpre-sin de GCL incrementa la sntesis de GSH (14)

reported that sulforaphane exerted a neuroprotective effect in a 6-OHDA-induced acute mouse model and attributed it to the ability of sulforaphane to enhance glutathione levels and its dependent enzymes, to up-regulate Nrf2 and to modulate the ERK1/2 pathway in the brain 28

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These systems play a critical role in protecting the structure and function of membrane systems and in sustaining cellular redox states ( 2 to H 2 O 2